Alkaline water does have a place for LPR sufferers like me because it deactivates the pepsin that has vaporized and deposited itself in my esophagus and throat which when activated by acidic foods will begin to digest my soft tissues. The rest of ways to sell it I agree are completely bunk.
The biggest initial issue for many is that it’s pretty sedating, but that lessens with time. I slept like the dead for the first three weeks as baclofen is one of the few drugs that increases the frequency and duration of deep sleep. Now I can take 100 milligrams in a day and not feel a thing. I have literally no side effects.
One downside is sudden cessation is hell. If I miss an entire day, my anxiety gradually increases until it’s through the roof until I start taking it again. Two days results in gradually increasing visual hallucinations. All of this completely reverses within an hour of taking a dose. You must taper off this stuff, but doing it isn’t hard at all. Just don’t go cold turkey.
It’s also a medication that people tend not to grow resistant to. It hasn’t lost any effectiveness for me despite having taken 60-80mg/day for almost two decades.
I used to have constant burning throat pain and the taste of stomach contents. Not anymore!
It reduces the frequency of transient lower esophageal sphincter (LES) relaxation and increases its resting tone. Here’s a relevant paper for anyone interested:
Alkaline water does have a place for LPR sufferers like me because it deactivates the pepsin that has vaporized and deposited itself in my esophagus and throat which when activated by acidic foods will begin to digest my soft tissues. The rest of ways to sell it I agree are completely bunk.
Huh, cool.
TIL, thank you. It indeed makes perfect sense that it would help for this.
Hey fellow LPR person! Ever looked into baclofen? It’s an oddball, but it helped me and a friend with our LPR.
No but I will take a look, thanks! Always pursuing any lead on this particular issue ;-).
Edit: took a look, looks like pretty serious stuff, any side effects?
The biggest initial issue for many is that it’s pretty sedating, but that lessens with time. I slept like the dead for the first three weeks as baclofen is one of the few drugs that increases the frequency and duration of deep sleep. Now I can take 100 milligrams in a day and not feel a thing. I have literally no side effects.
One downside is sudden cessation is hell. If I miss an entire day, my anxiety gradually increases until it’s through the roof until I start taking it again. Two days results in gradually increasing visual hallucinations. All of this completely reverses within an hour of taking a dose. You must taper off this stuff, but doing it isn’t hard at all. Just don’t go cold turkey.
It’s also a medication that people tend not to grow resistant to. It hasn’t lost any effectiveness for me despite having taken 60-80mg/day for almost two decades.
I used to have constant burning throat pain and the taste of stomach contents. Not anymore! It reduces the frequency of transient lower esophageal sphincter (LES) relaxation and increases its resting tone. Here’s a relevant paper for anyone interested:
https://pmc.ncbi.nlm.nih.gov/articles/PMC9981648/
Bonus: 20 mg for non-users will halt hiccups but will likely also sedate them pretty hard. 10-20 mg will prevent MDMA hyperthermia.