i think trans- denotes “change” or “movement”, right? trans-isomers are usually rotated from their cis state, trans-portation moves things between areas, trans-lation changes the language of a text.

all to say, i think the change in and of itself is significant, and not everyone who’s outside the “norm” feels a need to do it. there should probably be another term for that. too bad “heterogendered” conjures the imagery that it does.